Causes and Treatment of Habitual Abortion
Chromosomal Abnormality
Chromosomal abnormality can occur in the fetus if one of the parents (or both) has a chromosomal abnormality, and this can lead to recurrent miscarriages in the early stages of pregnancy. This is the case found in 6% of the couple who experience habitual abortion.
Even if the parents have normal chromosomes, there is a risk of chromosomal abnormality if the mother is over the age of 35. An aneuploidy, for example, Down syndrome, Patau, and Edward syndrome, may result from non-disjunction in the cell division process.
Uterus
15-25% of miscarriages are caused by uterine deformity and uterine synechiae (formation of intrauterine adhesions). In addition, (uterine myoma and cervical incompetence ) may also be the cause of miscarriages.
Infections
Viruses such as TORCH (Toxoplasmosis, Other (syphilis, etc.), Rubella, Cytomegalovirus (CMV), and Herpes infections), which can cause deformities in the fetus, as well as chlamydia, urea plasma and other bacteria can cause recurrent miscarriages. Antibiotic or anti-viral drug treatment may be necessary.
Endocrinologic factors
In case secretion of progesterone (luteinizing hormone) does not occur appropriately from ovulation to the early stages of pregnancy, defects may occur in the luteal phase. In addition, diabetes and thyroid diseases may also cause habitual abortion.
Immunological factors
Immunological factors are known to be the cause of approximately 50% of all miscarriages. They are divided into immunological abnormalities caused by auto antibodies and isoimmune abnormalities. Related conditions may be diagnosed by detecting auto antibodies that can potentially cause miscarriages and cells and cytokines involved in isoimmunity.
Unknown factors
Most cases of habitual abortions caused by an unknown factor are linked with immunological factors.
Accordingly, treatment is provided based on immunological factors.