Preimplantation Genetic Testing, PGT
Preimplantation genetic testing is a method to help you conceive a genetically normal fetus by diagnosing genetic diseases or chromosomal abnormalities at the embryo stage before implantation using IVF procedure, and then selecting and implanting only normal embryos. Genetic testing is performed by removing some cells from the fertilised embryo, and it is necessary to have a thorough consultation with your doctor about the limitations of the test method itself.
Preimplantation Genetic Testing for chromosomal Aneuploidies (PGT-A)
The risk of chromosomal abnormalities in embryos increases dramatically with increasing maternal age, and the presence of chromosomal abnormalities in embryos is associated with decreased pregnancy success and increased rates of spontaneous abortion. PGT-A is indicated for couples who do not have chromosomal abnormalities, but are concerned about pregnancy failure or habitual miscarriage due to an increased risk of chromosomal abnormalities in the embryo.
- ∙ Older women
- ∙ Habitual miscarriage
- ∙ Recurrent implantation failure
- ∙ Men with oligospermia
- ∙ Experience of pregnancy with a fetus with a chromosomal abnormality
Preimplantation Genetic Testing for chromosomal Structural Rearrangement (PGT-SR)
A structural abnormality in a chromosome is a rearrangement in the structure of a chromosome, such as a translocation, inversion, deletion, or duplication, that results in abnormal rejoining after the chromosome has been cut. Structural abnormalities are defined as balanced when all normal chromosome components are present, and unbalanced when parts of the chromosome are added or deleted. Carriers of balanced rearrangements typically do not show any phenotypic abnormalities, but they are more likely to produce gametes with unbalanced chromosomes, which can lead to miscarriage or the birth of a malformed child. Balanced rearrangements are also more commonly found in couples with habitual miscarriages or infertile men than in the general population, and should be confirmed by chromosome testing.
Preimplantation Genetic Testing for Monogenic disorder (PGT-M)
It is a method of selecting embryos that can be implanted at the preimplantation embryo stage by performing an in vitro fertilisation procedure on couples with muscular dystrophy and other genetic diseases prescribed by the Presidential Decree (Article 25, Paragraph 2 of the Act on Bioethics and Safety) or their carriers.
Download the list of accepted medical conditions in Korea
※Requirements and notices before implementing PGT-M
- ㆍA clinically accurate diagnosis of the mutation must be confirmed by genetic testing or chromosomal testing.
- ㆍYou might need a family tree and genetic information about your family members.
- ㆍIn some cases, you may need to draw blood from a family member.
- ㆍDue to technical limitations and cell mosaicism, it is possible to get a false negative or false positive result, so if you are pregnant, you are required to get an accurate prenatal examination to check for fetal abnormalities.